![]() Multiple epidermoid cysts may be encountered as irregularly distributed lesions on the whole body or localized grouped lesions which is common in the retroauricular area. Most lesions are sporadic but familial inheritance is also possible, especially in individuals with multiple lesions. These cysts may progress slowly for years. Although these cysts are recognized as benign lesions, rare malignancy can arise. They typically develop relating with bone if they are in the orbit. Conversely, epidermoid cysts can develop in any part of the body and are usually diagnosed later in life. Dermoid cysts are common, diagnosed during infancy or early childhood, usually located superficially or in the anterior orbit, commonly mold bone, and rarely induce bone lysis. Both are cystic choristomas filled with keratin, cholesterol clefts, or degenerated blood components, and produced by keratinizing squamous epithelium but whereas true dermoid cysts have skin appendages on their walls, epidermoid cysts wall do not have these appendages. The term "dermoid" also has been used extensively to describe dermoid and epidermoid cysts however, they are different entities. ![]() Other common synonyms include infundibular cyst, epidermal cyst, epidermal inclusion cyst and epidermoid inclusion cyst. ![]() It is the result of the proliferation of surface epidermoid cells within the dermis. The term sebaceous cyst, which has formerly been used as a synonym for epidermoid cyst, is inappropriate because of the absence of sebaceous glands within the cyst lining. An epidermoid cyst is a common type of cutaneous cyst with an epidermis-like epithelial lining (wall). In addition to occurring in many visceral organs, epidermoid cysts may also appear on the skin and mucous membranes. Also, a milium is considered epidermoid cyst occurring transient. Ĭutaneous cysts can be classified into three main types based on their morphology and specific pattern of differentiation include : (1) stratified squamous epithelium, (2) non-stratified squamous epithelium, (3) absence of epithelium in it, epidermoid cysts are folded into the group the first ( Table A1). ![]() However, some clinical and imaging features, including the location of the cyst, may serve as diagnostic clues leading to a presumptive diagnosis. Confirmation of the diagnosis is mostly via histopathologic examination. Generally, cutaneous cysts are round, dome-shaped, protruding, or deeply located dermal or subcutaneous papules or nodules seen at different locations. On the other hand, a subset of cysts, namely pseudocysts, is not lined by epithelium but instead is surrounded by connective or granulation tissue. Some cysts are surrounded by an epithelial cell wall, which is either stratified squamous or unstratified squamous epithelium. Various types of cutaneous cysts containing fluid or semi-solid material and showing variable histopathologic features and clinical significance have been defined. ![]()
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